TY  - BOOK
AU  - Frank, Steven A.
TI  - Dynamics of cancer:  incidence, inheritance, and evolution
SN  - 9780691133669 (pbk.)
U1  - 616.994071 23rd
PY  - 2007///
CY  - Princeton, N.J. : 
PB  - Princeton University Press, 
KW  - Cancer incidence
KW  - Stem cells
KW  - Population genetic
N1  - Includes appendix, references, author index& subject index
N2  - The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer
ER  -