000			a
999			_c1269 _d1269
003			OSt
005			20200929115359.0
008			200929b xxu||||| |||| 00| 0 eng d
020			_a9780691163840 (pbk.) : _c$24.95
040			_cIISER-BPR _dIISER-BPR
082			_a616.994 _bAKT/C _223rd.
100			_aAktipis, Athena
222			_aBIOLOGY
245			_aCheating cell: how evolution helps us understand and treat cancer / _cby Athena Aktipis
260			_aNew Jersey: _bPrinceton University Press, _cc2020
300			_axii, 238 p. : _bill. : _c24 cm.
500			_aIncludes Index.
520			_aSummary: A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don't necessarily think of evolution. But evolution and cancer are closely linked, for the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer's evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer's ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn't mean we should give up on treating cancer-in fact evolutionary approaches offer new and promising options for the disease's prevention and treatments that aim at long-term management rather than simple eradication. Looking across species-from sponges and cacti to dogs and elephants-we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future-and that we cannot win a war against evolution-treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer's fundamental nature and our relationship to it.
650			_aAdaptive oncogenesis
650			_aEvolution
650			_aImmunology
942			_2ddc _cBK