000			01633nam a2200241Ia 4500
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020			_a9780691133669 (pbk.) _c$ 67.50
040			_bENG _cIISER-BPR _dIISER-BPR
082			_a616.994071 _bFRA _223rd
100			_aFrank, Steven A. _95407
222			_aBiology
245			_aDynamics of cancer _b incidence, inheritance, and evolution
260			_aPrinceton, N.J. : _bPrinceton University Press, _c2007
300			_axi, 378p. : _bill. ; _e24cm
504			_aIncludes appendix, references, author index& subject index.
520			_aThe book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer.
650			_aCancer incidence _95408
650			_aStem cells _91643
650			_aPopulation genetic _95409
942			_cBK _2ddc
999			_c1912 _d1912