000			02178nam a2200241Ia 4500
003			OSt
005			20240905181820.0
008			240123b |||||||| |||| 00| 0 eng d
020			_a9780128037522
040			_cIISER BPR
041			_aENG
082			_a615.1 _bKEN _223rd
100			_aKenakin, Terry P.
222			_aChemistry
245			_aPharmacology in drug discovery and development : _bUnderstanding drug response
250			_a2nd ed.
260			_aLondon: _bAcademic Press; _cc2017
300			_axi, 326p. : _bill(.col). ; _c22cm
520			_aPharmacology in Drug Discovery and Development: Understanding Drug Response, Second Edition, is an introductory resource illustrating how pharmacology can be used to furnish the tools necessary to analyze different drug behavior and trace this behavior to its root cause or molecular mechanism of action. The concepts discussed in this book allow for the application of more predictive pharmacological procedures aimed at increasing therapeutic efficacy that will lead to more successful drug development. Chapters logically build upon one another to show how to characterize the pharmacology of any given molecule and allow for more informed predictions of drug effects in all biological systems. New chapters are dedicated to the interdisciplinary drug discovery environment in both industry and academia, and special techniques involved in new drug screening and lead optimization. This edition has been fully revised to address the latest advances and research related to real time kinetic assays, pluridimensional efficacy, signaling bias, irreversible and chemical antagonism, allosterically-induced bias, pharmacokinetics and safety, target and pathway validation, and much more. With numerous valuable chapter summaries, detailed references, practical examples and case studies throughout, Dr. Kenakin successfully navigates a highly complex subject, making it accessible for students, professors, and new researchers working in pharmacology and drug discovery. Includes references, appendix, illustrations and index.
650			_aPharmacology
650			_aDrug development
942			_2ddc _cBK _01
999			_c2960 _d2960